Evaluation of an Improved Non- invasive Fetal Sex Determination in Haemophilia A Patients
نویسندگان
چکیده
منابع مشابه
highly sensitive conventional pcr testing of free fetal dna in maternal serum for non-invasive fetal sex determination
background: free fetal dna (ffd) in maternal plasma/serum has increasingly become the source of fetal material for diagnostic purposes in recent years. this source of fetal material can be used for sex determination. rh typing paternally inherited sequences and compound heterozygosity. reports on the lack of consistent pcr amplification of y-chromosome sequences of ffd in maternal plasma/serum ...
متن کاملearly non-invasive determination of fetal sex using cell-free dna
the first step in the prenatal diagnosis of x-linked genetic disorders is determining fetus gender. current invasive methods to obtain the dna source of the fetus instead of its miscarriage risk, has harmful stress for high risk pregnancies. cell free fetal dna (cffdna) circulating in the maternal blood, has now become a useful source of noninvasive prenatal diagnosis. considering limitation of...
متن کاملNon-invasive fetal sex determination by maternal plasma sequencing and application in X-linked disorder counseling.
OBJECTIVE To develop a fetal sex determination method based on maternal plasma sequencing (MPS), assess its performance and potential use in X-linked disorder counseling. METHODS 900 cases of MPS data from a previous study were reviewed, in which 100 and 800 cases were used as training and validation set, respectively. The percentage of uniquely mapped sequencing reads on Y chromosome was cal...
متن کاملNon-invasive prenatal determination of fetal sex: translating research into clinical practice.
The effectiveness and clinical utility of non-invasive prenatal diagnosis (NIPD) for fetal sex determination using cell-free fetal DNA (cffDNA) was assessed by undertaking a prospective national audit of UK testing. NIPD was performed using real-time polymerase chain reaction analysis of the DYS14 or SRY gene in cffDNA extracted from maternal plasma. All cases referred for fetal sex determinati...
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ژورنال
عنوان ژورنال: JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
سال: 2015
ISSN: 2249-782X
DOI: 10.7860/jcdr/2015/12556.6175